Nootropil 800 mg: Cognitive Enhancement and Neuroprotection
| Product dosage: 800mg | |||
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Synonyms
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Nootropil 800 mg contains the active substance piracetam, a nootropic agent belonging to the racetam class, widely utilized in neurological and psychiatric practice. It is indicated for the management of cortical myoclonus and as adjunctive therapy for a range of cognitive disorders. Its primary mechanism of action, while not fully elucidated, is believed to involve modulation of neurotransmitter systems, improving neuronal membrane fluidity, and enhancing neuroplasticity, thereby supporting cognitive function and offering neuroprotective benefits. This product card provides a comprehensive, evidence-based overview for healthcare professionals and informed patients.
Features
- Active Ingredient: Piracetam 800 mg
- Drug Class: Nootropic agent (Racetam)
- Presentation: Film-coated tablets for oral administration
- Pharmacokinetics: Rapidly and almost completely absorbed after oral administration; peak plasma concentrations reached within 1 hour. Not metabolized; eliminated renally with a half-life of 4-5 hours.
- Bioavailability: Approximately 100%
Benefits
- Supports and enhances higher integrative cognitive functions, including learning, memory, and concentration.
- Provides a stabilizing effect on the neuronal membrane, contributing to neuroprotection.
- May improve the fluidity of neuronal membranes, facilitating interhemispheric communication via the corpus callosum.
- Can aid in the rehabilitation process following brain injury by supporting cognitive recovery.
- Offers a well-established safety profile with a low incidence of serious adverse events when used appropriately.
Common use
Nootropil (piracetam) is clinically employed for a spectrum of neurological conditions. Its primary and most robustly evidenced use is in the treatment of cortical myoclonus, either as monotherapy or in combination with other anticonvulsant agents. Furthermore, it is extensively used off-label and in some countries as a licensed adjunctive therapy for cognitive deficits. This includes cognitive impairment secondary to cerebrovascular events (e.g., post-stroke recovery), age-related cognitive decline (not meeting the criteria for dementia), vertigo of central origin, and dyslexia and related learning disabilities in children. Its application is always predicated on a thorough neurological assessment and diagnosis.
Dosage and direction
Dosage must be individualized based on renal function, indication, and patient response. The 800 mg tablet allows for convenient dosing.
- Adults (Cortical Myoclonus): Initial dosage is typically 7.2 g daily, divided into 2-3 doses. This is increased by 4.8 g daily every 3-4 days up to a maximum of 24 g daily, divided into 2-3 doses. Maintenance dose is often 12-24 g daily.
- Adults (Cognitive Impairment / Other Uses): Common dosages range from 2.4 g to 4.8 g daily, divided into 2-3 doses.
- Elderly: Dosage adjustment is necessary based on renal function. Initiate at a lower dose.
- Renal Impairment: Dosage must be significantly reduced. Please refer to the full prescribing information for detailed guidance based on creatinine clearance.
- Administration: Tablets should be swallowed whole with a sufficient amount of liquid, with or without food.
Precautions
- Renal Function: Piracetam is excreted unchanged by the kidneys. Use with extreme caution in patients with renal impairment; dosage adjustment is mandatory.
- Hemostasis: Use with caution in patients with a history of hemorrhagic diathesis or severe hemorrhage, as piracetam may affect platelet aggregation.
- Surgery: Discontinuation should be considered prior to major surgical procedures due to potential effects on hemostasis.
- Psychiatric Symptoms: In patients with history of major psychosis or anxiety, monitor for possible exacerbation of symptoms (e.g., agitation, confusion, insomnia).
- Pregnancy and Lactation: Avoid use during pregnancy unless clearly necessary. Piracetam is excreted in human milk; a decision should be made whether to discontinue nursing or discontinue the drug.
Contraindications
Nootropil is contraindicated in the following populations:
- Patients with known hypersensitivity to piracetam, other racetam derivatives, or any of the excipients in the formulation.
- Patients with severe renal impairment (creatinine clearance < 20 mL/min).
- Patients with Huntington’s chorea, due to the potential for exacerbating abnormal movements.
- Patients with cerebral hemorrhage (acute phase).
Possible side effect
Piracetam is generally well-tolerated. Most adverse reactions are mild and transient. Common side effects include:
- Nervous System Disorders: Nervousness, agitation, anxiety, insomnia, drowsiness, asthenia, headache, dizziness, tremor, hyperkinesia.
- Gastrointestinal Disorders: Nausea, vomiting, diarrhea, abdominal pain.
- Psychiatric Disorders: Depression, confusion, hallucinations (rare).
- Other: Weight gain, rash, pruritus.
Serious side effects are rare but may include severe hypersensitivity reactions, angioedema, and thrombophlebitis.
Drug interaction
- Anticoagulants/Antiplatelets (e.g., Warfarin, Aspirin, Clopidogrel): Piracetam may potentiate the effects of these drugs, increasing the risk of bleeding. Close monitoring of coagulation parameters is advised.
- Thyroid Hormones (e.g., Levothyroxine): Piracetam may cause a slight increase in serum T4 levels without affecting T3 levels; clinical significance is unclear.
- Central Nervous System Depressants (e.g., Alcohol, Benzodiazepines): May potentiate the effects of CNS depressants, leading to increased sedation.
- Antihypertensive Drugs: Piracetam has been associated with reports of decreased blood pressure; monitor patients on antihypertensive therapy.
Missed dose
If a dose is missed, it should be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped. Do not double the dose to make up for a missed one. Maintain the regular dosing schedule.
Overdose
Symptoms of overdose are largely an extension of its known adverse effects and may include severe diarrhea, abdominal pain, and pronounced drowsiness or agitation. There is no specific antidote. Management involves immediate gastric lavage (if ingestion was recent) and symptomatic supportive care. As piracetam is eliminated renally, adequate diuresis should be maintained. Hemodialysis is effective in removing piracetam from the bloodstream and should be considered in cases of severe overdose, particularly in patients with renal impairment.
Storage
- Store below 30°C (86°F).
- Keep the blister strips in the outer carton to protect from light and moisture.
- Keep out of the sight and reach of children.
- Do not use after the expiration date printed on the packaging.
Disclaimer
This information is intended for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is based on the typical properties of the drug and may not be fully comprehensive or reflect the most recent regulatory updates for your specific region.
Reviews
- “As a neurologist, I find Nootropil 800 mg to be a valuable tool in my armamentarium for managing post-stroke cognitive deficits. The dosage form is convenient for titrating to an effective level.” – Dr. A. Schmidt, MD (Neurology)
- “Prescribed for my mother’s age-related memory concerns. We noticed a modest but meaningful improvement in her focus and recall after several weeks of consistent use, under strict medical supervision.” – Family Caregiver
- “The evidence for its use in cortical myoclonus is strong. It has provided significant symptom reduction for several of my patients who were refractory to other treatments.” – Prof. J. Ellis, MD (Clinical Neurophysiology)
- “While more robust clinical trials are always welcome, the long history of use and favorable safety profile make piracetam a considered choice for off-label cognitive support in appropriate patients.” – Clinical Pharmacologist